TNFα and Endothelial IL-1 Receptor Signaling Drive Peritubular Capillary Regression and Fibrosis in Obstructive Kidney Injury
Charmain F. Johnson, Kate Wheeler, Jun Xie, J. C. M. Chan, George E. Davis, Courtney T. Griffin
This study identifies TNF and endothelial IL-1R1 signaling as key drivers of capillary regression and fibrosis in obstructive kidney injury, showing that their combined inhibition preserves peritubular capillaries and reduces renal injury.
bioRxiv · Dec 31, 2025 · PreprintPathology