Florea Lupu

This study identifies transcriptional networks that coordinate metabolic and secretory pathways in high endothelial cells (HECs) to support immune function and morphology.

This study uses a baboon model of sepsis to analyze cardiomyopathy through multimodal techniques, finding distinct transcriptomic and physiological differences between survivors and non-survivors.

This study shows that S1PR1 regulates lymphatic valve development and prevents tertiary lymphoid organ formation in the terminal ileum, suggesting TLOs as a sign of subclinical inflammation.

This paper shows that PROX1 inhibits PDGF-B expression in heart valves to prevent myxomatous degeneration, and PDGF-B inhibition ameliorates valve defects in mice.

This study shows that BRG1 and CHD4 regulate endothelial extracellular matrix components through epigenetic mechanisms, essential for proper lung development in mice.