Author

Katharina Foreman

Radboud University Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2

Frequent Co-Authors

Britt MossinkiD· 2 shared Dirk SchubertiD· 2 shared Jason M. Keller· 2 shared Katrin LindaiD· 2 shared Monica FregaiD· 2 shared Nael Nadif KasriiD· 2 shared Teun M. Klein GunnewiekiD· 2 shared Astrid R. Oudakker· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersNeuroscience

Britt MossinkORCID

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2 papers

Recent·Most cited

Mitochondrial dysfunction impairs human neuronal development and reduces neuronal network activity and synchronicity

Teun M. Klein Gunnewiek, Eline van Hugte, Monica Frega, Gemma Sole Guardia, Katharina Foreman, Daan M. Panneman, Britt Mossink, Katrin Linda, Jason M. Keller, Dirk Schubert, David M Cassiman, Richard J. Rodenburg, Noemi Vidal‐Folch, Devin Oglesbee, Ester Perales‐Clemente, , Tamás Kozicz

This study shows that mitochondrial dysfunction in human neurons, caused by high heteroplasmy of the m.3243A>G variant, leads to impaired neural development, reduced synaptic connectivity, and decreased network activity.

Cell Reports · Apr 1, 2020Peer-reviewedNeuroscience

Neuronal network dysfunction in a human model for Kleefstra syndrome mediated by enhanced NMDAR signaling

Monica Frega, Katrin Linda, Jason M. Keller, Guvem Gumus Akay, Britt Mossink, Jon-Ruben van Rhijn, Moritz Negwer, Teun M. Klein Gunnewiek, Katharina Foreman, Nine F. Kompier, Chantal Schoenmaker, Willem M.R. van den Akker, Ilse van der Werf, Astrid R. Oudakker, Huiqing Zhou, , Nael Nadif Kasri

This study shows that EHMT1 deficiency in human neurons leads to NMDAR hyperfunction, causing neuronal network dysfunction in Kleefstra syndrome, and demonstrates pharmacological rescue of these phenotypes.

Nature Communications · Oct 30, 2019Peer-reviewedNeuroscience