Human pluripotent stem cell-derived kidney organoids reveal tubular epithelial pathobiology of heterozygous HNF1B-associated dysplastic kidney malformations
Ioannis Bantounas, Kirsty M. Rooney, Filipa M. Lopes, Tengku Muhamad Faris Syafiq Tengku Zakaria, Woods Jon S, Leo A. H. Zeef, I‐Hsuan Lin, Shweta Yogesh Kuba, Nicola Bates, Sandra Hummelgaard, Katherine A. Hillman, Silvia Cereghini, Adrian S. Woolf, Susan J. Kimber
This study uses HNF1B mutant kidney organoids to reveal molecular and physiological defects in dysplastic kidney malformations and identify potential therapeutic targets.
Stem Cell Reports · May 23, 2024Peer-reviewedDevelopmental Biology