Author

Jianqiang Wu

Cincinnati Children's Hospital Medical CenterORCID 0000-0002-4239-5659Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Nancy RatneriD· 2 shared Tilat A. RizviiD· 2 shared Abby SchaeperiD· 1 shared Jay PundavelaiD· 1 shared Jennifer Patritti CramiD· 1 shared Jose A. Cancelas· 1 shared Katherine C Scheffer· 1 shared Katherine E. Chaney· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

Nancy RatnerORCID

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2 papers

Recent·Most cited

Selective Pyroptosis in NF1-Deficient Cells through PKCδ Agonism

Liang Hu, Yuting Tang, Yuan Lin, Jay Pundavela, Katherine C Scheffer, Abby Schaeper, Tilat A. Rizvi, Jianqiang Wu, Yi Zheng, Nancy Ratner

This study identifies PKCδ agonism as a method to selectively induce pyroptosis in NF1-deficient cells by targeting KRAS-GDP interactions.

bioRxiv · May 21, 2026 · PreprintCancer Biology

Purinergic receptor P2RY14 cAMP signaling regulates EGFR-driven Schwann cell precursor self-renewal and nerve tumor initiation in neurofibromatosis.

Jennifer Patritti Cram, Jianqiang Wu, Shinji Kuninaka, Robert A. Coover, Robert F. Hennigan, Tilat A. Rizvi, Katherine E. Chaney, Ramya Ravindran, Jose A. Cancelas, Robert J. Spinner, Nancy Ratner

This study identifies P2RY14 as a regulator of cAMP signaling in Schwann cell precursors, showing its role in self-renewal and neurofibroma initiation in NF1 mutant cells.

eLife · Mar 21, 2022Peer-reviewedNeuroscience