NeuroscienceNeurobiology of PainPeer-reviewed
Live cell imaging reveals paclitaxel-induced lysosome motility and function disruption in DRG neurons
Kathleen Cate Domalogdog, Ishwarya Sankaranarayanan, Úrzula Franco‐Enzástiga…·Theodore John Price
This study shows paclitaxel disrupts lysosome motility and function in DRG neurons, and MNK1/2 inhibition with eFT508 restores lysosomal signaling and alleviates CIPN.