Diana Tavares‐Ferreira

This study identifies E-selectin as a key driver of IL-1B-dependent neuroinflammation in vincristine-induced neuropathy and suggests targeting E-selectin as a therapeutic strategy.

This study shows paclitaxel disrupts lysosome motility and function in DRG neurons, and MNK1/2 inhibition with eFT508 restores lysosomal signaling and alleviates CIPN.

The paper identifies microglia-like cells in human dorsal root ganglia and shows their changes in diabetic neuropathy.

This study shows that translational control in spinal cord neurons, particularly in inhibitory and PV+ interneurons, significantly influences gene expression and pain hypersensitivity during the chronic phase of neuropathic pain.

The paper identifies OSMR and SST as molecular markers for human dermal sleeping nociceptors, providing new therapeutic targets for neuropathic pain.

The paper investigates neurodegeneration in dorsal root ganglia across diabetes and diabetic painful neuropathy stages, identifying early molecular changes and highlighting the need for early intervention.

This study identifies widespread microRNA dysregulation in diabetic peripheral neuropathy using small RNA-sequencing of human sural nerves, highlighting miR-21-5p's role in Schwann cells and its association with axonal loss.

The paper identifies neurotrophic signals, particularly FGF9, required for fracture healing by mapping somatosensory afferent circuitry to bone and analyzing gene expression changes in DRG neurons.

This study shows that 4E-BP2 controls specific mRNA translation in GABAergic interneurons, which is necessary for long-term memory formation.

This paper constructs a human dorsal root ganglion reference atlas, identifying 22 neuronal subtypes and 10 non-neuronal cell types, and reveals functional differences between human and mouse DRG neurons.

The paper maps molecular features of human spinal cord dorsal and ventral horns, identifying neuronal types and sex-specific glial differences using single-nucleus sequencing and spatial transcriptomics.

The paper investigates neuronal gene expression changes in skin biopsies from paclitaxel-induced peripheral neuropathy patients using bulk RNA sequencing and spatial transcriptomics.

This study uses bulk and spatial RNA sequencing to analyze human peripheral nerves in diabetic patients, revealing pathway differences, immune cell shifts, and mRNA localization changes linked to diabetic peripheral neuropathy.

This paper uses spatial transcriptomics to analyze human sympathetic chain ganglia in diabetes, identifying neuronal and non-neuronal changes linked to autonomic dysfunction.

The paper shows OSM-OSMR signaling via MAPKs drives transcriptomic changes in human DRG linked to neuropathic pain.

The paper characterizes human C2 dorsal root ganglion (DRG) using single-nucleus and spatial transcriptomics, identifying gene expression patterns linked to chronic neck pain.

The paper investigates FGFR3 expression in human peripheral nervous system tissues and finds no detectable mRNA or protein expression in nerve or dorsal root ganglia, suggesting FGFR3 autoantibodies may not directly cause neuropathy.

The paper uses single nuclei RNA sequencing and spatial transcriptomics to analyze human trigeminal nerves and neuromas, identifying molecular changes associated with neuropathic pain.

The paper identifies Nageotte nodules in diabetic painful neuropathy DRGs, showing they contain dead neurons and are linked to pain and sensory loss.

The paper identifies persistent changes in nociceptor mRNA translation following hyperalgesic priming and shows Gpr88 and Metrn regulate this state.

The paper builds harmonized cross-species cell atlases of DRG and TG, identifies 29 cell types across 6 species, and shows transcriptomic similarities and differences in sensory neurons.

The paper develops a comprehensive ncRNA atlas for human sensory neurons using iPSC-derived models and DRG sequencing, revealing ncRNA signatures across differentiation stages and highlighting their roles in nociceptor development.

This study reviews preclinical and clinical literature on prostaglandin signaling and finds sex differences in PTGDS expression in human sensory neurons.

This paper shows that ICOS agonist antibody alleviates paclitaxel-induced neuropathy in female mice via IL-10-mediated mechanisms, suggesting potential for CIPN treatment.

This study identifies the cellular distribution of matrisome genes in murine and human dorsal root ganglia, revealing their potential role in neuronal signaling and pain.

The paper investigates FMRP expression in human nociceptor axons of the spinal dorsal horn, finding it colocalizes with pain-related markers and suggests a role in sex dimorphic chronic pain mechanisms.

This paper shows that recombinant mouse Meteorin reduces paclitaxel-induced neuropathy in mice by reversing glial reactivity and preventing nerve fiber loss.

The paper profiles RNA in human DRGs from neuropathic pain patients, identifying sex-specific gene expression differences and neuro-immune pathways associated with pain.

The paper uses spatial transcriptomics to characterize human sensory neurons, comparing them to mouse and non-human primate data to identify similarities and divergences in drug targets.

The paper identifies sex differences in nociceptor translatomes, revealing sex-specific prostaglandin signaling differences in male and female mice.