Ishwarya Sankaranarayanan

History of opioid use disorder correlates with altered neuroimmune signatures in the human dorsal root ganglia

The paper examines molecular and physiological changes in dorsal root ganglia from individuals with and without opioid use disorder, identifying altered neuroimmune signatures and sensitized sensory neurons.

NaV1.7-dependent peripheral sensitization drives chronic pain in Parkinson's disease

This study identifies NaV1.7-dependent peripheral sensitization as a mechanism of chronic pain in Parkinson's disease and highlights CRMP2 regulation of NaV1.7 as a therapeutic target.

Live cell imaging reveals paclitaxel-induced lysosome motility and function disruption in DRG neurons

This study shows paclitaxel disrupts lysosome motility and function in DRG neurons, and MNK1/2 inhibition with eFT508 restores lysosomal signaling and alleviates CIPN.

Satellite microglia-like cells in human dorsal root ganglia and changes with diabetic neuropathy

The paper identifies microglia-like cells in human dorsal root ganglia and shows their changes in diabetic neuropathy.

Molecular architecture of human dermal sleeping nociceptors

The paper identifies OSMR and SST as molecular markers for human dermal sleeping nociceptors, providing new therapeutic targets for neuropathic pain.

Progressive neurodegeneration in human dorsal root ganglion from diabetes to painful neuropathy

The paper investigates neurodegeneration in dorsal root ganglia across diabetes and diabetic painful neuropathy stages, identifying early molecular changes and highlighting the need for early intervention.

Mapping Somatosensory Afferent Circuitry to Bone Identifies Neurotrophic Signals Required for Fracture Healing

The paper identifies neurotrophic signals, particularly FGF9, required for fracture healing by mapping somatosensory afferent circuitry to bone and analyzing gene expression changes in DRG neurons.

Meteorin resolves nociceptive hypersensitivity by reducing connexin-mediated coupling in satellite glial cells

This study shows meteorin reduces nociceptive hypersensitivity by decreasing connexin-mediated coupling in satellite glial cells, with long-lasting therapeutic effects in pain models.

GM-CSF instructs vertebral emergency myelopoiesis in neuropathic pain

This study identifies GM-CSF as a key mediator of vertebral bone marrow emergency myelopoiesis in neuropathic pain, linking meningeal immunity to pain pathogenesis.

Single-nuclei RNA Sequencing Reveals Distinct Transcriptomic Signatures of Rat Dorsal Root Ganglia in a Chronic Discogenic Low Back Pain Model

This study uses single-nuclei RNA sequencing to identify transcriptomic changes in rat dorsal root ganglia in a chronic discogenic low back pain model, linking gene expression to axial hypersensitivity.

A Reference Atlas of the Human Dorsal Root Ganglion

This paper constructs a human dorsal root ganglion reference atlas, identifying 22 neuronal subtypes and 10 non-neuronal cell types, and reveals functional differences between human and mouse DRG neurons.

Molecular and Functional Asymmetry in Cckar-expressing Vagal Sensory Neurons

The paper identifies a right-biased neuronal population in vagus nerves that expresses genes related to digestive signaling and may contribute to asymmetric reward processing.

Nerve-targeting and pain-promoting transcriptomic signatures in early Guillain-Barre syndrome

This study identifies transcriptomic signatures in GBS patients that reveal leukocyte interactions with peripheral nerves and pain pathways, suggesting therapeutic targets for neuropathic pain.

Deciphering the molecular landscape of human peripheral nerves: implications for diabetic peripheral neuropathy

This study uses bulk and spatial RNA sequencing to analyze human peripheral nerves in diabetic patients, revealing pathway differences, immune cell shifts, and mRNA localization changes linked to diabetic peripheral neuropathy.

Single cell transcriptional analysis of human adenoids identifies molecular features of airway microfold cells

This study uses snRNA-seq to identify molecular features of human airway microfold cells and discovers a novel epithelial cell type with an interferon-stimulated gene signature.

Mapping satellite glial cell heterogeneity reveals distinct spatial organization and signifies functional diversity in the dorsal root ganglion

The paper characterizes satellite glial cell (SGC) subtypes in mouse and human dorsal root ganglia using single-cell RNA sequencing and spatial techniques, revealing distinct functional roles and spatial organization.

Expansion of OSMR expression and signaling in the human dorsal root ganglion links OSM to neuropathic pain

The paper shows OSM-OSMR signaling via MAPKs drives transcriptomic changes in human DRG linked to neuropathic pain.

Single-cell characterization of the human C2 dorsal root ganglion recovered from C1-2 arthrodesis surgery: implications for neck pain

The paper characterizes human C2 dorsal root ganglion (DRG) using single-nucleus and spatial transcriptomics, identifying gene expression patterns linked to chronic neck pain.

Transcriptomic and histological characterization of telocytes in the human dorsal root ganglion

This study identifies CD34/PDGFRA+ cells in human dorsal root ganglia as putative telocytes, characterizes their subclusters, and shows their proximity to neurons and blood vessels without ultrastructural variation.

Investigation of cellular and molecular changes linked with neuropathic pain in healthy and injured human trigeminal nerves

The paper uses single nuclei RNA sequencing and spatial transcriptomics to analyze human trigeminal nerves and neuromas, identifying molecular changes associated with neuropathic pain.

Nageotte nodules in human DRG reveal neurodegeneration in painful diabetic neuropathy

The paper identifies Nageotte nodules in diabetic painful neuropathy DRGs, showing they contain dead neurons and are linked to pain and sensory loss.

Persistent changes in nociceptor translatomes govern hyperalgesic priming in mouse models

The paper identifies persistent changes in nociceptor mRNA translation following hyperalgesic priming and shows Gpr88 and Metrn regulate this state.

Harmonized cross-species cell atlases of trigeminal and dorsal root ganglia

The paper builds harmonized cross-species cell atlases of DRG and TG, identifies 29 cell types across 6 species, and shows transcriptomic similarities and differences in sensory neurons.

VLK drives extracellular phosphorylation of EphB2 to govern the EphB2-NMDAR interaction and injury-induced pain

This study identifies VLK as an extracellular kinase that mediates EphB2 phosphorylation and pain responses by regulating synaptic protein interactions.

Sex-differences in prostaglandin signaling: a semi-systematic review and characterization of PTGDS expression in human sensory neurons

This study reviews preclinical and clinical literature on prostaglandin signaling and finds sex differences in PTGDS expression in human sensory neurons.

Inducible co-stimulatory molecule (ICOS) alleviates Paclitaxel induced peripheral neuropathy via an IL-10-mediated mechanism in female mice

This paper shows that ICOS agonist antibody alleviates paclitaxel-induced neuropathy in female mice via IL-10-mediated mechanisms, suggesting potential for CIPN treatment.

Meteorin alleviates Paclitaxel-induced peripheral neuropathy in mice

This paper shows that recombinant mouse Meteorin reduces paclitaxel-induced neuropathy in mice by reversing glial reactivity and preventing nerve fiber loss.

RNA Profiling of Neuropathic Pain-Associated Human DRGs Reveal Sex-differences in Neuro-immune Interactions Promoting Pain

The paper profiles RNA in human DRGs from neuropathic pain patients, identifying sex-specific gene expression differences and neuro-immune pathways associated with pain.

Convergence of peptidergic and non-peptidergic protein markers in the human dorsal root ganglion and spinal dorsal horn

The paper examines the protein expression and central projections of nociceptor markers in human dorsal root ganglia and spinal cord, finding overlapping expression of CGRP and P2X3R and distinct projection patterns compared to mice.

Spatial transcriptomics reveals unique molecular fingerprints of human nociceptors

The paper uses spatial transcriptomics to characterize human sensory neurons, comparing them to mouse and non-human primate data to identify similarities and divergences in drug targets.