Úrzula Franco‐Enzástiga

The paper examines molecular and physiological changes in dorsal root ganglia from individuals with and without opioid use disorder, identifying altered neuroimmune signatures and sensitized sensory neurons.

This study shows paclitaxel disrupts lysosome motility and function in DRG neurons, and MNK1/2 inhibition with eFT508 restores lysosomal signaling and alleviates CIPN.

This paper identifies cell-type-specific genetic variants associated with chronic pain using GWAS and scRNA-seq data from brain and dorsal root ganglia tissues.

This study shows that type I interferons increase excitability of human dorsal root ganglion nociceptors and sensitize TRPV1, contributing to pain.

The paper shows OSM-OSMR signaling via MAPKs drives transcriptomic changes in human DRG linked to neuropathic pain.

The paper examines sex differences in the epigenomic landscape of human dorsal root ganglia, identifying sex-specific chromatin accessibility and transcription factor binding patterns associated with nociceptive gene regulation.

The paper integrates human DRG proteomics with multi-omic data to identify TNFα signalling as a sexually dimorphic pathway in the PNS.

The paper shows vinorelbine induces neuropathic pain-like state in mice through STING and MNK1 signaling linked to type I IFN induction in DRG neurons.

This study shows type I interferons act directly on nociceptors via MNK-eIF4E signaling to cause pain hypersensitivity in mice, linking viral infections to pain and neuropathies.