Ribosomal RNA synthesis by RNA polymerase I is subject to premature termination of transcription.
Chaïma Azouzi, Katrin Schwank, Sophie Queillé, Marta Kwapisz, Marion Aguirrebengoa, Anthony K. Henras, Simon Lebaron, Herbert Tschochner, Annick Lesne, Frédéric Beckouët, Olivier Gadal, Christophe Dez
The paper shows that premature termination of transcription by RNA polymerase I limits rRNA production and that a mutant polymerase, SuperPol, reduces this termination, increasing rRNA output.
eLife · Feb 12, 2026Peer-reviewedMolecular Biology