Christophe Dez

Ribosomal RNA synthesis by RNA polymerase I is subject to premature termination of transcription.

The paper shows that premature termination of transcription by RNA polymerase I limits rRNA production and that a mutant polymerase, SuperPol, reduces this termination, increasing rRNA output.

Genetic analyses led to the discovery of a super-active mutant of the RNA polymerase I

The paper identifies mutations in RNA polymerase I that enhance its activity, leading to increased rRNA production in yeast.

A ribosome assembly stress response regulates transcription to maintain proteome homeostasis

The paper shows that ribosome assembly stress triggers a pathway that balances Hsf1 and Ifh1 activity to prevent proteotoxic stress in yeast.