Olivier Gadal

The paper shows that premature termination of transcription by RNA polymerase I limits rRNA production and that a mutant polymerase, SuperPol, reduces this termination, increasing rRNA output.

This study characterizes the subcellular localization and nuclear import mechanisms of yeast RNA exosome subunits, revealing their nucleolar distribution and interactions with importins and cofactors.

The paper shows that sister chromatid cohesion inhibits cohesin-mediated DNA loop expansion during G2 phase.

The paper investigates how transcription and cohesin complexes influence genome organization in yeast, showing transcription induces DNA borders and loops independently of SMC complexes.

The paper investigates how Scc2, Smc3 acetylation, and Pds5 regulate cohesin-dependent chromatin loop expansion during the cell cycle.

The paper identifies mutations in RNA polymerase I that enhance its activity, leading to increased rRNA production in yeast.

The paper shows that ribosome assembly stress triggers a pathway that balances Hsf1 and Ifh1 activity to prevent proteotoxic stress in yeast.

The paper models chromatin fiber dynamics in vivo, finding that transcription affects chromatin fluctuations through internal friction and transient contacts.

The paper identifies Eco1's role in negatively regulating cohesin translocase activity during yeast mitosis, affecting DNA loop extrusion and chromosome folding.