Annick Lesne

The paper shows that premature termination of transcription by RNA polymerase I limits rRNA production and that a mutant polymerase, SuperPol, reduces this termination, increasing rRNA output.

This paper investigates the distribution of disease-associated SNPs relative to 3D genome topological domains and finds that cancer risk loci are preferentially located at TAD borders.

Boost-HiC enhances long-range chromosomal contact maps by improving resolution using sparse data, enabling detection of Hi-C patterns with reduced sequencing depth.