Increased activity of IRE1 improves the clinical presentation of EAE
Valerie C. Bracchi-Ricard, Kayla Nguyen, Daniela Ricci, Brian T. Gaudette, Jorge Henao‐Mejia, Roberta Brambilla, Tetyana Martynyuk, Tali Gidalevitz, David Allman, John R. Bethea, Yair Argon
This study shows that increased IRE1 activity in a mouse model of EAE reduces inflammation and improves motor function, suggesting context-dependent protective effects of ER stress.
The FASEB Journal · Nov 20, 2023Peer-reviewedNeuroscience