Linear ubiquitination triggers Amph-mediated T-tubule biogenesis
Kohei Kawaguchi, Yutaro Hama, Harunori Yoshikawa, Kohei Nishino, Kazuki Morimoto, Tsuyoshi S. Nakamura, Michiko Koizumi, Yuriko Sakamaki, Kota Abe, Soichiro Kakuta, Koichiro Ichimura, Fumiyo Ikeda, Hidetaka Kosako, Naonobu Fujita
This study identifies LUBEL/RNF31 as a key regulator of T-tubule biogenesis through linear ubiquitination, showing its interaction with Amphiphysin and role in membrane tubulation.
Science Advances · Jan 7, 2026Peer-reviewedCell Biology