Human CDK5-cyclin B1 structures uncover a conserved mitotic CDK activation mechanism
Andrew S. Arvai, Ke Cong, Xiao-Feng Zheng, Amy Verway-Cohen, Miaw-Sheue Tsai, Huy Q. Nguyen, Albino Bacolla, Chi-Lin Tsai, George A. Lantz, Alexander Spektor, Dipanjan Chowdhury, John A. Tainer, Aleem Syed
The paper determines the first high-resolution crystal structures of CDK5-cyclin B1, revealing its mitotic activation mechanism similar to CDK1-cyclin B1.
bioRxiv · Sep 10, 2025 · PreprintBiochemistry