Author

Aleem Syed

Harvard UniversityORCID 0000-0001-7942-3900Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Alan D. D’AndreaiD· 3 shared Amira ElbakryiD· 2 shared Dipanjan ChowdhuryiD· 2 shared Huy Q. NguyeniD· 2 shared John A. TaineriD· 2 shared Roger A. GreenbergiD· 2 shared Sirisha MukkavalliiD· 2 shared Albino BacollaiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMolecular Biology

Alan D. D’AndreaORCID

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4 papers

Recent·Most cited

Molecular BiologyProceedings of the National Academy of SciencesPeer-reviewedJan 2, 2026

CHAMP1 Complex Promotes Heterochromatin Assembly and Reduces Replication Stress

Feng Li, Amira Elbakry, Felix Y. Zhou…·Alan D. D’Andrea

This study identifies the CHAMP1 complex as a regulator of heterochromatin assembly and replication fork stability, showing its role in preventing genomic instability in cancer cells.

3 citationstop 5%

humanDNA methylation

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BiochemistrybioRxivPreprintSep 10, 2025

Human CDK5-cyclin B1 structures uncover a conserved mitotic CDK activation mechanism

Andrew S. Arvai, Ke Cong, Xiao-Feng Zheng…·Aleem Syed

The paper determines the first high-resolution crystal structures of CDK5-cyclin B1, revealing its mitotic activation mechanism similar to CDK1-cyclin B1.

DOI 10.1101/2025.09.10.675329

humanprotein structure

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Molecular BiologyNature CommunicationsPeer-reviewedFeb 17, 2025

CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair

Feng Li, Tianpeng Zhang, Aleem Syed…·Alan D. D’Andrea

This study identifies the CHAMP1 complex's role in heterochromatin assembly and its enhancement of homology-directed DNA repair in specific genomic regions.

13 citations

humanmouse

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Molecular BiologyNature Structural & Molecular BiologyPeer-reviewedSep 11, 2023

Dynamics of the DYNLL1/MRE11 complex regulates DNA end resection and recruitment of the Shieldin complex to DSBs

Michelle L. Swift, Rui Zhou, Aleem Syed…·Dipanjan Chowdhury

This study shows how DYNLL1 and Shieldin regulate DNA end resection and repair pathway choice through interactions with MRE11 and 53BP1 at DSBs.

27 citations

humanexperimental assay

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