INTS12 Bridges Integrator and NELF to Prevent the Release of Non-processive RNA Polymerase II Complexes
Laura Corso, S. Rivera, Aleen Al Halawani, Chloe A. N. Gerak, Dáire Gannon, Oliver Ozaydin, Mengbo Li, Kedhar Thyagarajan, Lukasz Niezabitowski, Ngee Kiat Chua, Winnie Tan, Susanne I. Wudy, Aoife McLysaght, Gordon K. Smyth, Shabih Shakeel, , Stephin J. Vervoort
This paper identifies INTS12's role in stabilizing the Integrator-NELF complex to prevent the release of defective RNA Polymerase II complexes, showing its importance in transcription regulation and cellular toxicity.
bioRxiv · Jan 17, 2026 · PreprintMolecular Biology