In vivo-Active Soluble Epoxide Hydrolase-targeting PROTACs with Improved Potency and Stability
Keita Nakane, Christophe H.P. Morisseau, Presley D. Dowker-Key, Gabrielle Benitez, Jennifer T. Aguilan, Emiko Nagai, Simone Sidoli, Bruce D. Hammock, Ahmed Bettaieb, Kosaku Shinoda, Seiya Kitamura
This paper develops next-generation sEH-targeting PROTACs with improved potency and stability, showing effective degradation in mouse tissues.
ACS Medicinal Chemistry Letters · Oct 3, 2024Peer-reviewedBiochemistry