Saxiphilin functions as a "toxin sponge" protein that counteracts the effects of saxitoxin poisoning
Samantha A. Nixon, Sandra Zakrzewska, Seil Jang, Keli Huang, Anissa Bara, Zhou Chen, Daynen R Goss, Elizabeth R. Park, J. Du Bois, Daniel L. Minor
This study shows that RcSxph from American bullfrogs can counteract saxitoxin poisoning in mice by binding the toxin, validating its role as a toxin sponge.
Nature Communications · Jul 16, 2026Peer-reviewedPharmacology & Toxicology