Elizabeth R. Park

This study shows that RcSxph from American bullfrogs can counteract saxitoxin poisoning in mice by binding the toxin, validating its role as a toxin sponge.

This study identifies saxiphilin as a toxin sponge that binds multiple C13-modified saxitoxin congeners, revealing structural adaptability and conformational plasticity in toxin-protein interactions.

This paper develops a chemogenetic tool to selectively inhibit specific voltage-gated sodium channel subtypes with high precision and reversibility.

This paper identifies the structural basis for saxitoxin congener binding and neutralization by saxiphilins, showing how these proteins sequester toxins and reverse sodium channel blockage.