Selective decoupling of IgG1 binding to viral Fc receptorsrestores antibody-mediated NK cell activation against HCMV-infected cells
Ahlam N. Qerqez, Katja Hoffmann, Alison G. Lee, Sumit Pareek, Kelli Hager, Akaash Kumar Mishra, George Delidakis, Kirsten Bentley, Lauren E. Kerr-Jones, Mica Cabrera, Truong Nguyen, Rebecca L. Göttler, Amjad A. Chowdhury, Philipp Kolb, Hartmut Hengel, , Jennifer A. Maynard
This paper engineers IgG1 antibodies with modified Fc domains to resist viral Fc receptor binding, enhancing NK cell activation and reducing HCMV spread in infected cells.
Cell Reports · Dec 1, 2025Peer-reviewedImmunology