Genetic variation in the activity of a TREM2-p53 signaling axis determines oxygen-inducedlung injury
Yohei Abe, Nathanael J. Spann, Wenxi Tang, Fenghua Zeng, Cadence Seymour, Sean Jansky, Jason L. Guo, Robert M. Huff, Kelly Chanthavixay, John Lalith Charles Richard, Miguel Mooney, Debanjan Dhar, Souradipta Ganguly, David M. Lopez, Michael Thornton Longaker, , Enikö Sajti
The paper identifies TREM2-p53 signaling as a determinant of oxygen-induced lung injury in mice, showing that TREM2 loss reduces inflammation and improves lung development.
Nature Immunology · Jul 25, 2025Peer-reviewedImmunology