Network Analysis and Human Single Cell Brain Transcriptomics Reveal Novel Aspects of Alpha-Synuclein (SNCA) Biology
Erin A. Teeple, Khushboo Jindal, Beril Kiragasi, Siddharth Annaldasula, Ann Byrne, Lilly Chai, Mahdiar Sadeghi, Can Kayatekin, Srinivas Shankara, Katherine Wood Klinger, S. Pablo Sardi, Stephen L. Madden, Dinesh Kumar
The paper identifies a conserved SNCA co-expression module in human brain single-nucleus RNA-seq data and links it to Parkinson's Disease risk loci through protein-protein interaction networks and CRISPR validation.
bioRxiv · Jun 5, 2020 · PreprintNeuroscience