Author

Stephen L. Madden

Translational Sciences (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genomics· 2 Genetic & Genomic Medicine· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Assay:scRNA-seq· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Approach:experimental assay· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Dinesh KumariD· 4 shared Erin A. TeepleiD· 4 shared Katherine Wood Klinger· 4 shared S. Pablo SardiiD· 4 shared Deepak K. RajpaliD· 3 shared Amilcar Flores‐Morales· 2 shared Ángel Cedazo-Mı́ngueziD· 2 shared Mahdiar SadeghiiD· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersGenomics

Dinesh KumarORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Single Nuclei Sequencing of Human Putamen Oligodendrocytes Reveals Altered Heterogeneity and Disease-Associated Changes in Parkinson's Disease and Multiple System Atrophy

Erin A. Teeple, Pooja K. Joshi, Rahul Pande, Yinyin Huang, Akshat Karambe, Martine Latta‐Mahieu, S. Pablo Sardi, Ángel Cedazo-Mı́nguez, Katherine Wood Klinger, Amilcar Flores‐Morales, Stephen L. Madden, Deepak K. Rajpal, Dinesh Kumar

The paper profiles single nuclei from human putamen in Parkinson's Disease and Multiple System Atrophy, revealing disease-specific oligodendrocyte heterogeneity and gene expression changes.

bioRxiv · May 6, 2021 · PreprintGenomics

Single Cell Atlas of Human Putamen Reveals Disease Specific Changes in Synucleinopathies: Parkinson's Disease and Multiple System Atrophy

Rahul Pande, Yinyin Huang, Erin A. Teeple, Pooja K. Joshi, Amilcar Flores‐Morales, Martine Latta‐Mahieu, S. Pablo Sardi, Ángel Cedazo-Mı́nguez, Katherine Wood Klinger, Stephen L. Madden, Deepak K. Rajpal, Dinesh Kumar

The paper constructs a single-cell atlas of human putamen tissue from healthy controls, Parkinson's Disease, and Multiple System Atrophy to identify cell-type specific disease changes.

bioRxiv · May 6, 2021 · PreprintGenomics

Genome-Wide Polygenic Risk Score Identifies Individuals at Elevated Parkinson's Disease Risk

Yingnan Han, Erin A. Teeple, Srinivas Shankara, Mahdiar Sadeghi, Cheng Zhu, Dongyu Liu, FinnGen, Clarence Wang, Francesca Frau, Katherine Wood Klinger, Stephen L. Madden, Deepak K. Rajpal, S. Pablo Sardi, Dinesh Kumar

This paper computes a genome-wide polygenic risk score for Parkinson's Disease using 6.2 million variants and finds it strongly associates with increased disease risk and earlier onset.

medRxiv · Oct 16, 2020 · PreprintGenetic & Genomic Medicine

Network Analysis and Human Single Cell Brain Transcriptomics Reveal Novel Aspects of Alpha-Synuclein (SNCA) Biology

Erin A. Teeple, Khushboo Jindal, Beril Kiragasi, Siddharth Annaldasula, Ann Byrne, Lilly Chai, Mahdiar Sadeghi, Can Kayatekin, Srinivas Shankara, Katherine Wood Klinger, S. Pablo Sardi, Stephen L. Madden, Dinesh Kumar

The paper identifies a conserved SNCA co-expression module in human brain single-nucleus RNA-seq data and links it to Parkinson's Disease risk loci through protein-protein interaction networks and CRISPR validation.

bioRxiv · Jun 5, 2020 · PreprintNeuroscience