Mahdiar Sadeghi

The paper develops a quantitative pharmacology model to analyze how TCE drug-target trimer formation and biodistribution depend on binding kinetics and design characteristics.

The paper shows microglia are susceptible to ferroptosis in neurodegenerative diseases and identifies SEC24B and small molecules that regulate this process.

This study analyzes epidemic models under social distancing to find optimal timing and duration for minimizing infected population peaks while reducing social distancing time.

This paper computes a genome-wide polygenic risk score for Parkinson's Disease using 6.2 million variants and finds it strongly associates with increased disease risk and earlier onset.

The paper identifies a conserved SNCA co-expression module in human brain single-nucleus RNA-seq data and links it to Parkinson's Disease risk loci through protein-protein interaction networks and CRISPR validation.

The paper analyzes the periodic gain of the Ribosome Flow Model (RFM) and derives conditions for its optimality in translation elongation.