Next-generation enhancer AAVs for selective interspecies targeting of midbrain dopaminergic neurons
Kian A. Caplan, Ke Chen, Martin Wienisch, Yongqi Wang, Ruoyang Chai, In-Hye Kang, Cindy Szyin Chen, Ricardo C.H. del Rosario, Fenna M. Krienen, Fan Wang, Guoping Feng
The paper develops and benchmarks enhancer-AAVs for selective targeting of midbrain dopaminergic neurons across species, identifying a specific enhancer and optimizing AAV backbones to improve specificity and efficiency.
bioRxiv · Nov 6, 2025 · PreprintNeuroscience