Author

Martin Wienisch

Broad InstituteORCID 0000-0002-5599-8205Unclaimed ORCID profile · follow to get notified of new preprints

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Martin Wienisch1 paper

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Guoping FengiD· 3 shared Fenna M. KrieneniD· 2 shared Qiangge ZhangiD· 2 shared Ricardo C.H. del RosarioiD· 2 shared Abigail Mauermann· 1 shared Alec Wysoker· 1 shared Alyssa Lutservitz· 1 shared Andrew HarrahilliD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Guoping FengORCID

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3 papers

Recent·Most cited

Next-generation enhancer AAVs for selective interspecies targeting of midbrain dopaminergic neurons

Kian A. Caplan, Ke Chen, Martin Wienisch, Yongqi Wang, Ruoyang Chai, In-Hye Kang, Cindy Szyin Chen, Ricardo C.H. del Rosario, Fenna M. Krienen, Fan Wang, Guoping Feng

The paper develops and benchmarks enhancer-AAVs for selective targeting of midbrain dopaminergic neurons across species, identifying a specific enhancer and optimizing AAV backbones to improve specificity and efficiency.

bioRxiv · Nov 6, 2025 · PreprintNeuroscience

A marmoset brain cell census reveals influence of developmental origin and functional class on neuronal identity

Fenna M. Krienen, Kirsten M. Levandowski, Heather Zaniewski, Ricardo C.H. del Rosario, Margaret E. Schroeder, Melissa Goldman, Martin Wienisch, Alyssa Lutservitz, Victoria F. Beja-Glasser, Cindy Chen, Qiangge Zhang, Ken Y. Chan, Katelyn X. Li, Jitendra Sharma, Dana M. McCormack, , Guoping Feng

The paper analyzes single-nucleus RNA sequencing data from marmoset brain cells to show that neuronal identity is more influenced by developmental origin than functional class.

Science Advances · Oct 12, 2023Peer-reviewedNeuroscience

Efficient Zygotic Genome Editing via RAD51-Enhanced Interhomolog Repair

Jonathan J. Wilde, Tomomi Aida, Martin Wienisch, Qiangge Zhang, Peimin Qi, Guoping Feng

This study demonstrates that RAD51 enhances interhomolog repair in zygotes, enabling efficient homozygous knock-in without exogenous templates.

bioRxiv · Aug 6, 2018 · PreprintMolecular Biology