Fenna M. Krienen

This study shows lactation remodels the maternal lung to enhance innate defense against respiratory pathogens through epithelial changes, vascular remodeling, and granulocyte recruitment.

The paper identifies sibling-derived chimerism in microglia and macrophages across marmoset tissues using single-cell RNA-seq, showing hematopoietic origin and regional variation in brain microglia.

PIANO integrates single-cell data across species and modalities, models gene expression, and scales to 100 million cells for drug perturbation analysis.

The paper creates a cross-species consensus atlas of primate basal ganglia cell types using multiomic data from human, macaque, and marmoset, identifying 61 conserved cell types and a novel hybrid medium spiny neuron type.

This paper creates a cross-species spatial transcriptomic atlas of the basal ganglia in human, rhesus macaque, and common marmoset, revealing conserved molecular organization and cell type-specific compartments.

The paper presents a spatially resolved transcriptomic and gene regulatory atlas of primate subcortical regions, revealing spatially tuned transcriptional and regulatory programs across cell types.

The paper introduces PIANO, a variational autoencoder for multi-omics integration, showing improved performance on single-species and multi-atlas datasets.

The paper develops and benchmarks enhancer-AAVs for selective targeting of midbrain dopaminergic neurons across species, identifying a specific enhancer and optimizing AAV backbones to improve specificity and efficiency.

The paper analyzes the conservation and evolution of striatal interneurons across mammals, finding that TAC3 interneurons are conserved and that neuronal types evolve through redistribution and refinement.

The paper compares distractibility between marmosets and macaques in cognitive tasks and links it to dopamine D1 receptor expression in prefrontal parvalbumin neurons.

GASTON-Mix identifies spatial domains and gradients in SRT data more accurately than existing methods, revealing biological insights in brain and tumor tissues.

The paper examines single neuron diversity in primate visual cortical areas V1 and LPFC, finding differences in morphology, electrophysiology, and intrinsic bursting that may underlie functional specialization.

The paper investigates how astrocyte regional specialization develops in mouse and marmoset brains using single-nucleus RNA sequencing and expansion microscopy, finding significant regional and developmental changes in gene expression and morphology.

This study shows that calcium-permeable AMPA receptors (CP-AMPARs) in PV interneurons reduce their feature selectivity, and removing them increases selectivity in visual cortex and hippocampus.

This study shows that kynurenic acid (KYNA) and its enzyme KAT II expand in primate dlPFC, impairing cognitive functions by affecting NMDA and nic-7Rs, and suggests targeting KYNA as a therapeutic approach for neuroinflammatory disorders.

The paper analyzes single-nucleus RNA sequencing data from marmoset brain cells to show that neuronal identity is more influenced by developmental origin than functional class.

This study uses single nucleus transcriptomics to compare human and non-human primate cortical tissues, identifying human-specific gene expression patterns and their potential functional roles.

The paper analyzes gene regulatory programs in the neocortex of rodents and primates using single-cell multiomics, finding rapid evolution of cell type-specific gene expression and TE-driven cCREs.

The paper compares cellular diversity in the primary motor cortex across human, marmoset, and mouse using single-nucleus transcriptomics and epigenomics, finding conserved cell types and species-specific adaptations.

The paper generates a multimodal cell census and atlas of the mammalian primary motor cortex, revealing a unified molecular genetic landscape and cross-species taxonomy of cell types.

The paper profiles interneurons in primates and rodents to identify evolutionary innovations in brain cell types and their molecular features.

This paper constructs a single-cell atlas of the adult mouse brain, identifying 565 transcriptionally distinct cell groups and revealing new insights into neuronal specialization and brain organization.