Mutanome-guided immunopeptidomics of blood plasma for neoepitope detection in solid tumors is constrained by cfDNA variant calling sensitivity and MS detection limits
Andreas Kienzle, Jonas Philipp Becker, Birgit Fendl, Erwin Tomasich, Gerwin Heller, Kathrin Wellach, Kiana Samimi, Britta Eiz-Vesper, Angelika M. Starzer, Julia Maria Berger, Vincent Sunder-Plassmann, Barbara Kiesel, Christoph Bock, Georg Widhalm, Matthias Preusser, , Angelika Beate Riemer
The paper uses plasma immunopeptidomics guided by mutanomes to detect neoepitopes in solid tumors, finding that cfDNA variant calling sensitivity and MS detection limits constrain plasma-based detection.
bioRxiv · Sep 26, 2026 · PreprintImmunology