LncRNA-mediated organization of oncogenic chromatin state is a targetable vulnerability in leukemia
Ly Vu, Zhen Jin, Brenda Ma, Karen Chan, Diana Lin, Debajeet Ghosh, Amber Louwagie, Luke Saville, Joanne Liani Chandra, Yilin Liu, Zongmin Liu, Leo Escano, Sandra Spencer Miko, Se Wing Grace Cheng, Priscila Elias Ferreira Stricker, , Pieter R. Cullis
This study identifies PAN3-AS1 as an oncogenic lncRNA in AML, shows its role in chromatin organization, and demonstrates RNA-targeting LNP therapy to reduce leukemia burden.
bioRxiv · Aug 11, 2026 · PreprintCancer Biology