Retrograde signalling mediates cellular adaptation to mitochondrial DNA copy number alterations
Alissa Benedikt, Kim Job, Xiaoping Li, Soumodeep Sarkar, Luisa Hernández Götz, I. V. Kukhtevich, Francesco Padovani, Yagya Chadha, Jurgita Paukštytė, Juha Saarikangas, Jan Marcel Skotheim, Robert Schneider, Matthew P. Swaffer, Antonio Scialdone, Michael Charles Lanz, , Kurt M. Schmoller
This study shows that yeast cells adapt to changes in mitochondrial DNA copy number through retrograde signaling and protein dosage compensation, allowing robust growth despite mtDNA fluctuations.
bioRxiv · Apr 24, 2026 · PreprintCell Biology