Author

Juha Saarikangas

University of HelsinkiORCID 0000-0002-4665-2544Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Benjamin Thomas GoultiD· 2 shared Neil J. BalliD· 2 shared Vignesh Srinivasan· 2 shared Y OtaniiD· 2 shared Alissa BenediktiD· 1 shared Andreas KöhleriD· 1 shared Antonio ScialdoneiD· 1 shared Emily GoodalliD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersNeuroscience

Benjamin Thomas GoultORCID

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3 papers

Recent·Most cited

An internal PDZ-binding motif in Densin-180 promotes activity-dependent SHANK scaffold remodelling

Y Otani, Vignesh Srinivasan, Julia Töller, Till Kallem, Neil J. Ball, Igor Barsukov, Juha Saarikangas, Hans‐Jürgen Kreienkamp, Benjamin Thomas Goult

This study identifies an internal PDZ-binding motif in Densin-180 that promotes SHANK scaffold remodelling through activity-dependent interactions.

bioRxiv · Jul 10, 2026 · PreprintNeuroscience

Retrograde signalling mediates cellular adaptation to mitochondrial DNA copy number alterations

Alissa Benedikt, Kim Job, Xiaoping Li, Soumodeep Sarkar, Luisa Hernández Götz, I. V. Kukhtevich, Francesco Padovani, Yagya Chadha, Jurgita Paukštytė, Juha Saarikangas, Jan Marcel Skotheim, Robert Schneider, Matthew P. Swaffer, Antonio Scialdone, Michael Charles Lanz, , Kurt M. Schmoller

This study shows that yeast cells adapt to changes in mitochondrial DNA copy number through retrograde signaling and protein dosage compensation, allowing robust growth despite mtDNA fluctuations.

bioRxiv · Apr 24, 2026 · PreprintCell Biology

Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains

Y Otani, Emily Goodall, Vignesh Srinivasan, Neil J. Ball, Samuel F. H. Barnett, Tobias Zech, Juha Saarikangas, Benjamin Thomas Goult

This paper identifies how CDKL5 is anchored at the postsynaptic density via interactions with PDZ domains and talin, and shows that its spatial positioning is regulated by talin's mechanical properties.

bioRxiv · Aug 27, 2025 · PreprintNeuroscience