Impacts of different SETD1A mutations and genetic backgrounds on human induced pluripotent stem cell-derived hippocampal neurons
Yan Hong, Ting Zhao, Qian Yang, Hanwen Zhang, Xueting Ma, Xiao Su, Jiayi Liu, Siwei Zhang, Karla Mendez-Maldonado, Yi Zhou, Jizhong Zou, Anat Kreimer, Akira Sawa, Kimberly Christian, Zhiping Pang, , Guo-li Ming
This study examines how different SETD1A mutations and genetic backgrounds affect human hippocampal neurons derived from hiPSCs, revealing divergent molecular and cellular phenotypes and contrasting mutation impacts.
bioRxiv · Oct 11, 2026 · PreprintNeuroscience