Endogenous recapitulation of Alzheimers disease neuropathology through human 3D direct neuronal reprogramming
Zhao Qing Sun, Ji‐Sun Kwon, Yudong Ren, Shawei Chen, Kitra Cates, Xinguo Lu, Courtney K. Walker, Hande Karahan, Sanja Sviben, James A. J. Fitzpatrick, Clarissa Valdez, Henry Houlden, Celeste M M. Karch, Randall John Bateman, Chihiro Sato, , Andrew S.J. Yoo
This study uses 3D direct neuronal reprogramming of AD patient fibroblasts to recapitulate AD neuropathology, showing A{beta} deposition, tauopathy, and neuronal death, and identifies potential therapeutic targets.
Science · Aug 1, 2024Peer-reviewedNeuroscience