Author

Clarissa Valdez

Northwestern University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Abhay Gupta· 1 shared Adrian M. BebenekiD· 1 shared Anderson S. Peck· 1 shared Andrew S.J. YooiD· 1 shared Celeste M M. KarchiD· 1 shared Chad R. HaneyiD· 1 shared Chihiro SatoiD· 1 shared Courtney K. WalkeriD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperNeuroscience

Abhay Gupta

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Endogenous recapitulation of Alzheimers disease neuropathology through human 3D direct neuronal reprogramming

Zhao Qing Sun, Ji‐Sun Kwon, Yudong Ren, Shawei Chen, Kitra Cates, Xinguo Lu, Courtney K. Walker, Hande Karahan, Sanja Sviben, James A. J. Fitzpatrick, Clarissa Valdez, Henry Houlden, Celeste M M. Karch, Randall John Bateman, Chihiro Sato, , Andrew S.J. Yoo

This study uses 3D direct neuronal reprogramming of AD patient fibroblasts to recapitulate AD neuropathology, showing A{beta} deposition, tauopathy, and neuronal death, and identifies potential therapeutic targets.

Science · Aug 1, 2024Peer-reviewedNeuroscience

The therapeutic and diagnostic potential of amyloid β oligomers (AβOs) selective antibodies to treat Alzheimer's disease

Kirsten L. Viola, Maira Assunção Bicca, Adrian M. Bebenek, Daniel L. Kranz, Vikas Nandwana, Emily Alexandria Waters, Chad R. Haney, Maxwell Y Lee, Abhay Gupta, Zachary Brahmbhatt, Weijian Huang, Ting-Tung A. Chang, Anderson S. Peck, Clarissa Valdez, Vinayak P. Dravid, William L. Klein

This paper demonstrates that amyloid β oligomers (AβOs) are key drivers of Alzheimer's disease pathology and shows that AβO-selective antibodies can restore memory function and serve as diagnostic tools.

Frontiers in Neuroscience · Jan 3, 2022Peer-reviewedNeuroscience