Andrew S.J. Yoo

The human-specific lncRNA HD-LINC drives lipid droplet-associated neurodegeneration in Huntington's disease

This study identifies HD-LINC, a human-specific lncRNA, as a driver of lipid droplet-associated neurodegeneration in Huntington's disease, showing its role in lipid metabolism and neuronal death.

Large-scale Perturbation of Systems Biology-Derived Genes Reveals Modifiers of HD-associated Transcriptomic Networks and Pathology

The paper uses genetic perturbations to identify modifiers of HD-associated transcriptomic networks and pathology in mice and patient-derived neurons.

Sequelae and reversal of age-dependent alterations in mitochondrial dynamics via autophagy enhancement in reprogrammed human neurons

This study investigates age-related changes in mitochondrial dynamics and autophagy in reprogrammed human neurons, finding that autophagy enhancement can reverse these age-dependent alterations.

Notch Inhibition Enhances Morphological Reprogramming of microRNA-Induced Human Neurons

This study shows that inhibiting Notch signaling enhances neurite outgrowth in microRNA-induced human neurons by accelerating fate erasure and silencing anti-neuronal genes.

Endogenous recapitulation of Alzheimers disease neuropathology through human 3D direct neuronal reprogramming

This study uses 3D direct neuronal reprogramming of AD patient fibroblasts to recapitulate AD neuropathology, showing A{beta} deposition, tauopathy, and neuronal death, and identifies potential therapeutic targets.

Multi-OMIC analysis of Huntington disease reveals a neuroprotective astrocyte state

This study uses multi-omic analysis to identify a neuroprotective astrocyte state in Huntington disease that correlates with delayed disease onset and neuroprotection.

MiR-124 synergism with ELAVL3 enhances target gene expression to promote neuronal maturity

The paper identifies miR-124's role in promoting neuronal maturity by enhancing target gene expression through interaction with ELAVL3.