James A. J. Fitzpatrick

Contextual High-throughput 3D Volume Electron Microscopy Data Acquisition Using Artificial Intelligence

The paper introduces an AI-driven method to improve 3D volume electron microscopy data acquisition by dynamically adjusting resolution, reducing acquisition time across various organisms and tissues.

Endogenous recapitulation of Alzheimers disease neuropathology through human 3D direct neuronal reprogramming

This study uses 3D direct neuronal reprogramming of AD patient fibroblasts to recapitulate AD neuropathology, showing A{beta} deposition, tauopathy, and neuronal death, and identifies potential therapeutic targets.

Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue

This study determines the atomic structure of alpha-synuclein fibrils from Lewy body dementia tissue using a novel amplification method and solid-state NMR.

Global cerebrospinal fluid circulation mapping using gold nanoparticle enhanced X-ray microtomography reveals region-specific brain and spinal cord CSF pathways

This study maps CSF pathways in the CNS using gold nanoparticle enhanced X-ray microtomography and identifies region-specific circulation patterns affecting stem cell and neuronal populations.