Evolution of an Aurora Kinase A Inhibitor from an Essential tRNA Synthetase
James Julian Ross, Polina Tikanova, Andreas Hagmüller, Daniel Krogull, Keyu Xiao, Casper van Bavel, Till Balla, Tianhua Liao, Kolin Angello Echano, Joseph Gokcezade, Peter Duchek, Danny D. Nedialkova, Rob Jelier, Gang Dong, Alejandro R. Burga
The paper shows how a duplicated tRNA synthetase evolved into a novel toxin by losing its ancestral function and acquiring a new role in targeting Aurora kinase A.
bioRxiv · Jun 10, 2026 · PreprintEvolutionary Biology