Cell-type-resolved RNP topologies reveal dynamic structural mechanisms of splicing and therapeutic targets
Jianhui Bai, Kongpan Li, Wei Zhang, Minjie Zhang, Grant M. Shoffner, Willem A. Velema, Jianfu Chen, Feng Guo, Zhipeng Lu
The paper introduces SHARCLIP to map RNA-RNA, RNA-protein, and protein-protein contacts in cells, revealing structural mechanisms of splicing and therapeutic targets.
bioRxiv · May 18, 2026 · PreprintMolecular Biology