Minjie Zhang

This paper introduces CRISPR-StAR, an in vivo CRISPR screening platform with improved normalization and analysis tools, showing it can identify tumor suppressor gene effects not observable in vitro.

The paper describes the process for analyzing RNA sequencing data from crosslink-ligation experiments to detect RNA structures and interactions.

The paper identifies HBS1L as a synthetic lethal target in FOCAD-deleted cancer through combinatorial CRISPR screens and validates its dependency via genetic manipulation and in vivo experiments.

The paper introduces computational tools to analyze crosslink-ligation RNA data, revealing new RNA structures and homodimers.

The paper introduces PARIS2, a method for efficiently analyzing RNA structures and interactions in cells, revealing new insights into viral RNA conformations and translation mechanisms.