Quality control at the Golgi couples membrane proteostasis to lipid metabolism
David Teis, Sinead Schwabl, Yannick Weyer, Javier Lizarrondo, Yuan Wang, Lisa Pupetschek, Astha Purwar, Konstantin Siegmann, Stefan Redl, Michael Hess, Agnès Michel, Alesia Yakimchyk, Klaus Faserl, Bettina Sarg, Benoı̂t Kornmann, , Florian Wilfling
The paper identifies a Golgi quality control checkpoint in yeast that links membrane proteostasis to lipid metabolism, showing that lipid imbalance from proteostasis defects is lethal.
bioRxiv · Oct 27, 2026 · PreprintCell Biology