Javier Lizarrondo

The paper identifies a Golgi quality control checkpoint in yeast that links membrane proteostasis to lipid metabolism, showing that lipid imbalance from proteostasis defects is lethal.

This study shows that LLOMe forms amyloid structures inside lysosomes that mechanically rupture the lysosomal membrane, revealing a structural mechanism for lysosomal damage.

The paper determines the molecular structure of autophagic cargo condensates using cryo-electron tomography and shows how disordered regions influence condensate properties.

Cryo-ET of Parkin-expressing U2OS cells shows oligomycin/antimycin depolarization moves some ATP synthase to the inner boundary membrane, abolishes matrix calcium granules, and favors closed prohibitin domes.