Bettina Sarg

Quality control at the Golgi couples membrane proteostasis to lipid metabolism

The paper identifies a Golgi quality control checkpoint in yeast that links membrane proteostasis to lipid metabolism, showing that lipid imbalance from proteostasis defects is lethal.

Ex Vivo Assay for Organ-Specific Cancer Cell Invasion

This paper develops an ex vivo model using organ-derived ECM scaffolds to study cancer cell invasion, showing organ-specific invasion patterns that match clinical observations.

Acute lysosome repositioning reveals functional and proteomic adaptations

The paper develops a method to reposition lysosomes and identifies proteomic differences between perinuclear and peripheral lysosomes.

TXNIP mediates LAT1/SLC7A5 endocytosis to reduce amino acid uptake in cells entering quiescence

The paper identifies TXNIP as a regulator of amino acid uptake during cellular quiescence by mediating endocytosis of the LAT1/SLC7A5 transporter.

The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi

This study identifies the Dsc ubiquitin ligase complex as a quality control mechanism at the Golgi that degrades orphaned proteins by assessing transmembrane domain hydrophobicity.

Multiplex genetic engineering exploiting pyrimidine salvage pathway-based self-encoded selectable markers

This paper introduces a novel genetic engineering method using endogenous pyrimidine salvage pathway genes as selectable markers for targeted DNA insertion in fungal pathogens.