Author

Kristen Lee

University of British ColumbiaPrimary ORCID profile (0000-0002-6837-9569 · 5 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Kristen LeeiD5 papers · Altius Institute for Biomedical Sciences

Biology Disciplines

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Neuroscience· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Annie Vogel CierniaiD· 2 shared Olivia Sullivan· 2 shared Abdullah M. Madany· 1 shared Ajay Paul SinghiD· 1 shared Anthony Shafer· 1 shared Bohan DengiD· 1 shared Brandon Wong· 1 shared Cal RoseteiD· 1 shared

Activity by Year

2014-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersNeuroscience

Annie Vogel CierniaORCID

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3 papers

Recent·Most cited

Early-Life Gut Inflammation Drives Sex-Dependent Shifts in the Microbiome-Endocrine-Brain Axis

Olivia Sullivan, Claire Sie, Katharine M. Ng, Sophie Cotton, Cal Rosete, Jordan E. Hamden, Ajay Paul Singh, Kristen Lee, Jatin Choudhary, Jennifer Ahjin Kim, Huaxu Yu, Charlotte A Clayton, Natalia A Carranza Garcia, Kateryna Voznyuk, Bohan Deng, , Annie Vogel Ciernia

This study investigates how early-life gut inflammation affects microbiome, endocrine, and behavioral outcomes, revealing sex-specific impacts on microbiota composition, hormone levels, and behavior.

Brain Behavior and Immunity · Dec 12, 2024Peer-reviewedNeuroscience

Repeated LPS induces training and tolerance of microglial responses across brain regions

Jennifer S. Kim, Olivia Sullivan, Kristen Lee, Justin Jao, Juan Tamayo, Abdullah M. Madany, Brandon Wong, Paul Ashwood, Annie Vogel Ciernia

This study shows that repeated LPS exposure induces training and tolerance in microglial responses across brain regions, with distinct gene expression patterns and morphological changes.

Journal of Neuroinflammation · Sep 20, 2024Peer-reviewedNeuroscience

DNA methylation modulates transcription factor occupancy chiefly at sites of high intrinsic cell-type variability

Matthew Maurano T, Hao Wang, Sam John, Anthony Shafer, Theresa Canfield, Kristen Lee, John A Stamatoyannopoulos

This study shows DNA methylation primarily stabilizes transcription factor binding at sites with high cell-type variability, not broadly repressing TF occupancy.

bioRxiv · Feb 27, 2014 · PreprintGenomics