Paul Ashwood

Genetic survey of biomarkers across pregnancy identifies pregnancy-specialized immune regulation

The paper conducts a genetic analysis of immune biomarkers across pregnancy timepoints, identifying heritable and genome-wide significant associations and highlighting timepoint-specific and pregnancy-unique findings.

Repeated LPS induces training and tolerance of microglial responses across brain regions

This study shows that repeated LPS exposure induces training and tolerance in microglial responses across brain regions, with distinct gene expression patterns and morphological changes.

Genetic variants drive altered epigenetic regulation of endotoxin tolerance in BTBR macrophages

The paper shows BTBR mouse genetic variants lead to altered chromatin accessibility and hyper-responsive innate immunity in macrophages, linking genetic differences to ASD-related immune abnormalities.

Microglia from offspring of dams with allergic asthma exhibit epigenomic alterations in genes dysregulated in autism

The paper investigates epigenomic and transcriptomic changes in microglia from offspring of dams with allergic asthma, finding links to autism-related gene dysregulation.