Identification of unique and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries
Dario Akaberi, Monireh Pourghasemi Lati, Janina Krambrich, Julia Berger, Grace Neilsen, Emilia Strandback, S. Pauliina Turunen, Johan Wannberg, Hjalmar Gullberg, Martin Moche, Praveen Kumar Chinthakindi, Tomas Nyman, Stefan G. Sarafianos, Anja Sandström, Josef D. Järhult, , Johan Lennerstrand
This paper identifies potent SARS-CoV-2 main protease inhibitors from a DNA-encoded chemical library using affinity-based selection, achieving an IC50 of 30 nM for compound SLL11.
Antimicrobial Agents and Chemotherapy · Aug 28, 2024Peer-reviewedMicrobiology