Marc Bickle

An integrated platform for high-throughput phenospace learning of 3D multilineage organoid systems

The paper introduces a platform for high-throughput spatial phenotyping of multilineage organoids, identifying pathway modulators and treatment strategies for PDAC.

A genome-wide RNA interference screening reveals protectiveness of SNX5 knockdown in a Parkinson`s disease cell model

The paper identifies SNX5 knockdown as protective against alpha-synuclein toxicity in a Parkinson's disease cell model through genome-wide RNA interference screening.

Modeling host-microbe interactions in immunocompetent engineered human gut tissues

The paper develops engineered human gut tissues to study host-microbe interactions and identifies an epithelial gene regulatory network in response to Salmonella Typhimurium infection.

Statistical integration of multi-omics and drug screening data from cell lines

The paper presents a computational workflow integrating multi-omics and drug screening data from cell lines to identify druggable pathways in synucleinopathies.

Phenotype loss is associated with widespread divergence of the gene regulatory landscape in evolution

The paper shows that loss of morphological traits in snakes and subterranean mammals is linked to widespread divergence of regulatory elements associated with those traits.