Lysyl oxidase drives ccRCC progression by coordinating HIF-2α transcription program with tumor microenvironment
Bürge Ulukan, Özge Saatci, Ariel Madrigal, Minjun Kim, Wensheng Tian, Mustafa Soytaş, Zohreh Mehrjoo, Ozlem Sener Sahin, Kukkamadi Sreenivas, C.N.R. Rao, Tamiko Nishimura, Virginie Pillon, Jean-Sebastian Anoma, Elizabeth Hill, Janusz Rak, , Ozgur Sahin
This study identifies LOX as a driver of ccRCC progression by sustaining HIF-2α transcription and modulating the tumor microenvironment.
bioRxiv · Jul 27, 2026 · PreprintCancer Biology