Central pore-opening structure and gating of the mechanosensitive PIEZO1 channel
Sijia Liu, Xuzhong Yang, Xudong Chen, Xiaochun Zhang, Jinghui Jiang, Li Wang, Jingyi Yuan, Wenhao Liu, Heng Zhou, Kun Wu, Boxue Tian, Xueming Li, Bailong Xiao
This study defines the structural states and curvature-based activation/inactivation mechanisms of PIEZO1 using a mutant and molecular dynamics simulations.
bioRxiv · Sep 28, 2023 · PreprintNeuroscience